Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …

Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two
major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Chemoresistance of cancer cells is a major problem in treating cancer. Knowledge of how
cancer cells may die or resist cancer drugs is critical to providing certain strategies to …

Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins.
Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer …

Accumulating evidence suggests that pyroptosis, apoptosis and necroptosis are deeply
involved in cancer immunity. However, the role of PANoptosis in gastric cancer (GC) …

Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage
of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely …