Activation of NRF2 by epiberberine improves oxidative stress and insulin resistance in T2DM mice and IR-HepG2 cells in an AMPK dependent manner
S Zhang, S Zhang, Y Zhang, H Wang, Y Chen… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Phytochemical compounds offer a distinctive edge in
diabetes management, attributed to their multifaceted target mechanisms and minimal …
diabetes management, attributed to their multifaceted target mechanisms and minimal …
Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa …
M Yao, J Cao, L Zhang, K Wang, H Lin… - Journal of Agricultural …, 2024 - ACS Publications
Indole-3-lactic acid (ILA) has exhibited antimicrobial properties. However, its role in
inhibiting Helicobacter pylori infection remains elusive. This study investigated the inhibitory …
inhibiting Helicobacter pylori infection remains elusive. This study investigated the inhibitory …
Synthesis and anti-ureolitic activity of Biginelli adducts derived from formylphenyl boronic acids
NEM Costa, PHC Dos Santos, VGS Medeiros… - Bioorganic …, 2024 - Elsevier
Urease is a metalloenzyme that contains two Ni (II) ions in its active site and catalyzes the
hydrolysis of urea into ammonia and carbon dioxide. The development of effective urease …
hydrolysis of urea into ammonia and carbon dioxide. The development of effective urease …
Phosvitin phosphopeptides alleviate the inhibitory effect of oxidative stress on osteoblast function through FoxO/Wnt signaling
W Liu, M Abou-Elsoud, M Salama, L Ding, Z Cai… - Food Bioscience, 2024 - Elsevier
Oxidative stress inhibits osteoblast differentiation and function, leading to the development
of osteoporosis. The effects of Phosvitin phosphopeptides (PPPs) on the osteogenic function …
of osteoporosis. The effects of Phosvitin phosphopeptides (PPPs) on the osteogenic function …
Discovery and evolution of berberine analogues as anti-Helicobacter pylori agents with multi-target mechanisms
X Zhang, G Wang, W Kuang, L Xu, Y He, L Zhou… - Bioorganic …, 2024 - Elsevier
Thirty protoberberine derivatives, of which twenty five were new, were synthesized and
evaluated for their anti-Helicobacter pylori (HP) activities, taking 2, 3, 10-trimethoxy-9-p …
evaluated for their anti-Helicobacter pylori (HP) activities, taking 2, 3, 10-trimethoxy-9-p …
基于谱效关联分析和网络药理学研究连蒲双清散药效物质及作用靶点
齐小雨， 刘星彤， 孙一丹， 候冉冉， 李秋， 刘志海… - 中国畜牧兽医, 2024 - chvm.net
[目的] 基于试验设计构建连蒲双清散抗炎抑菌的谱效关联分析, 并结合网络药理及体内外试验
揭示其药效物质基础及作用机制.[方法] 选取黄连蒲公英比例, 提取酸浓度, 乙醇浓度为影响因素 …
揭示其药效物质基础及作用机制.[方法] 选取黄连蒲公英比例, 提取酸浓度, 乙醇浓度为影响因素 …