Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15
Coronaviruses have evolved a wide array of tactics to evade host antiviral immunity. When
host cells detect invading foreign nucleic acids including viral genome and viral replication …
host cells detect invading foreign nucleic acids including viral genome and viral replication …
[HTML][HTML] Regulation of coronavirus nsp15 cleavage specificity by RNA structure
I Salukhe, R Choi, W Van Voorhis, L Barrett, J Hyde - PLoS One, 2023 - journals.plos.org
SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, has had an enduring impact
on global public health. However, SARS-CoV-2 is only one of multiple pathogenic human …
on global public health. However, SARS-CoV-2 is only one of multiple pathogenic human …
[HTML][HTML] Lessons learnt from COVID-19: computational strategies for facing present and future pandemics
Since its outbreak in December 2019, the COVID-19 pandemic has caused the death of
more than 6.5 million people around the world. The high transmissibility of its causative …
more than 6.5 million people around the world. The high transmissibility of its causative …
[HTML][HTML] Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser
NendoU from SARS-CoV-2 is responsible for the virus's ability to evade the innate immune
system by cleaving the polyuridine leader sequence of antisense viral RNA. Here we report …
system by cleaving the polyuridine leader sequence of antisense viral RNA. Here we report …
[HTML][HTML] Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection
Abstract Coronavirus disease 19 (COVID-19) is caused by a highly contagious RNA virus
Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), originated in December …
Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), originated in December …
[HTML][HTML] Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and …
Background and aim The ongoing global pandemic due to SARS-CoV-2 caused a medical
emergency. Since December 2019, the COVID-19 disease is spread across the globe …
emergency. Since December 2019, the COVID-19 disease is spread across the globe …
[HTML][HTML] The nsp15 nuclease as a good target to combat SARS-CoV-2: mechanism of action and its inactivation with FDA-approved drugs
M Saramago, VG Costa, CS Souza, C Bárria… - Microorganisms, 2022 - mdpi.com
The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …
[HTML][HTML] SARS-CoV-2 and the DNA damage response
RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
ORF3c is expressed in SARS‐CoV‐2‐infected cells and inhibits innate sensing by targeting MAVS
M Müller, A Herrmann, S Fujita, K Uriu, C Kruth… - EMBO …, 2023 - embopress.org
Most SARS‐CoV‐2 proteins are translated from subgenomic RNAs (sgRNAs). While the
majority of these sgRNAs are monocistronic, some viral mRNAs encode more than one …
majority of these sgRNAs are monocistronic, some viral mRNAs encode more than one …
Immune evasion of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); molecular approaches
In December 2019, a new betacoronavirus, known as severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), caused an outbreak at the Wuhan seafood market in China …
coronavirus-2 (SARS-CoV-2), caused an outbreak at the Wuhan seafood market in China …