Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Myocardial ischemia or reperfusion increases the generation of reactive oxygen species
(ROS) from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

The human heart's failure to replace ischemia-damaged myocardium with regenerated
muscle contributes significantly to the worldwide morbidity and mortality associated with …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Background Remote ischemic preconditioning (RIPC) initiates endogenous protective
pathways in the brain from a distance and represents a new, promising paradigm in …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …

Met tyrosine kinase receptor, also known as c-Met, is the HGF (hepatocyte growth factor)
receptor. The HGF/Met pathway has a prominent role in cardiovascular remodelling after …