The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020
Y Liu, C Liang, L Xin, X Ren, L Tian, X Ju, H Li… - European journal of …, 2020 - Elsevier
This review fully describes the coronavirus 3CL pro peptidomimetic inhibitors and
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …
Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease
JFW Chan, SKP Lau, KKW To… - Clinical microbiology …, 2015 - Am Soc Microbiol
The source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife
market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led …
market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led …
The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022
X Pang, W Xu, Y Liu, H Li, L Chen - European Journal of Medicinal …, 2023 - Elsevier
The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …
From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
R Hilgenfeld - The FEBS journal, 2014 - Wiley Online Library
This review focuses on the important contributions that macromolecular crystallography has
made over the past 12 years to elucidating structures and mechanisms of the essential …
made over the past 12 years to elucidating structures and mechanisms of the essential …
[HTML][HTML] Potential use of polyphenols in the battle against COVID-19
Highlights•Polyphenols interact with SARS-CoV-2 viral proteins and its human cellular
targets.•Virus binding, entry and replication are affected by these plant-derived compounds.• …
targets.•Virus binding, entry and replication are affected by these plant-derived compounds.• …
Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2
A Du, R Zheng, C Disoma, S Li, Z Chen, S Li… - International journal of …, 2021 - Elsevier
SARS-CoV-2 is the etiological agent responsible for the ongoing pandemic of coronavirus
disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive …
disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive …
[PDF][PDF] Antivirals with common targets against highly pathogenic viruses
Historically, emerging viruses appear constantly and have cost millions of human lives.
Currently, climate change and intense globalization have created favorable conditions for …
Currently, climate change and intense globalization have created favorable conditions for …
Discovery of New Hydroxyethylamine Analogs against 3CLpro Protein Target of SARS-CoV-2: Molecular Docking, Molecular Dynamics Simulation, and Structure …
The novel coronavirus, SARS-CoV-2, has caused a recent pandemic called COVID-19 and
a severe health threat around the world. In the current situation, the virus is rapidly …
a severe health threat around the world. In the current situation, the virus is rapidly …
From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
R Hilgenfeld, M Peiris - Antiviral research, 2013 - Elsevier
This article introduces a series of invited papers in Antiviral Research marking the 10th
anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a …
anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a …
Evaluation of acridinedione analogs as potential SARS-CoV-2 main protease inhibitors and their comparison with repurposed anti-viral drugs
Abstract Background The main protease (Mpro) of SARS-CoV-2 is involved in the
processing of vital polypeptides required for viral genome replication and transcription and …
processing of vital polypeptides required for viral genome replication and transcription and …