[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …
that outcomes are markedly heterogeneous between patients. This requires identifying the …
[HTML][HTML] Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics
MA Alamri, A Altharawi, AB Alabbas… - Arabian Journal of …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has affected almost every country in the
world by causing a global pandemic with a high mortality rate. Lack of an effective vaccine …
world by causing a global pandemic with a high mortality rate. Lack of an effective vaccine …
An updated review on SARS-CoV-2 main Proteinase (MPro): protein structure and small-molecule inhibitors
Coronaviruses (CoVs) are enveloped positive-stranded RNA viruses with spike (S) protein
projections that allow the virus to enter and infect host cells. The S protein is a key virulence …
projections that allow the virus to enter and infect host cells. The S protein is a key virulence …
Exploration of novel lichen compounds as inhibitors of SARS-CoV-2 Mpro: ligand-based design, molecular dynamics, and ADMET analyses
Abstract In the year 2019–2020, the whole world witnessed the spread of a disease called
COVID-19 caused by SARS-CoV-2. A number of effective drugs and vaccine has been …
COVID-19 caused by SARS-CoV-2. A number of effective drugs and vaccine has been …
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors
Specific anti-coronaviral drugs complementing available vaccines are urgently needed to
fight the COVID-19 pandemic. Given its high conservation across the betacoronavirus genus …
fight the COVID-19 pandemic. Given its high conservation across the betacoronavirus genus …
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective
T Pillaiyar, LL Wendt, M Manickam… - Medicinal research …, 2021 - Wiley Online Library
Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause
respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal …
respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal …
Review on development of potential inhibitors of SARS-CoV-2 main protease (MPro)
SG Katre, AJ Asnani, K Pratyush, NG Sakharkar… - Future Journal of …, 2022 - Springer
Background The etiological agent for the coronavirus illness outbreak in 2019–2020 is a
novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors
Y Shimamoto, Y Hattori, K Kobayashi, K Teruya… - Bioorganic & medicinal …, 2015 - Elsevier
The design and evaluation of a novel decahydroisoquinolin scaffold as an inhibitor for
severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL pro) are …
severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL pro) are …
The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
Z Jin, H Wang, Y Duan, H Yang - Biochemical and Biophysical Research …, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health …
In-silico screening of plant-derived antivirals against main protease, 3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2
Abstract Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition
all over the world. The virus is highly infectious and spreads by human to human local …
all over the world. The virus is highly infectious and spreads by human to human local …