The PI3K/Akt pathway in meta-inflammation

M Acosta-Martinez, MZ Cabail - International journal of molecular …, 2022 - mdpi.com
Obesity is a global epidemic representing a serious public health burden as it is a major risk
factor for the development of cardiovascular disease, stroke and all-cause mortality. Chronic …

Insulin resistance, hyperglycemia, and atherosclerosis

KE Bornfeldt, I Tabas - Cell metabolism, 2011 - cell.com
Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by
the epidemic of type 2 diabetes. Further advances in this area demand a thorough …

How western diet and lifestyle drive the pandemic of obesity and civilization diseases

W Kopp - Diabetes, metabolic syndrome and obesity: targets and …, 2019 - Taylor & Francis
Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

K Yamamoto, H Takeshita, H Rakugi - Clinical Science, 2020 - portlandpress.com
Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

Non-alcoholic fatty liver disease and hypertension: coprevalent or correlated?

D Oikonomou, G Georgiopoulos, V Katsi… - European journal of …, 2018 - journals.lww.com
Objective To provide a comprehensive review summarizing the existing evidence on the
association between nonalcoholic fatty liver disease (NAFLD) and hypertension (HT) …

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes

CH Mandavia, AR Aroor, VG DeMarco, JR Sowers - Life sciences, 2013 - Elsevier
Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence
bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is …

Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome

W Li, C Liu, Q Yang, Y Zhou, M Liu, H Shan - Frontiers in Nutrition, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease that is
characterized by oligo-ovulation or anovulation, hyperandrogenism, and polycystic ovaries …

[HTML][HTML] Role of adipose tissue renin–angiotensin system in metabolic and inflammatory diseases associated with obesity

L Yvan-Charvet, A Quignard-Boulangé - Kidney international, 2011 - Elsevier
Obesity is a leading cause of death worldwide because of its associated inflammatory
disorders such as hypertension, cardiovascular and kidney diseases, dyslipidemia, glucose …

Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells

C Cramer, E Freisinger, RK Jones… - Stem cells and …, 2010 - liebertpub.com
Type 2 diabetes is associated with numerous long-term complications. This study aims to
investigate whether impaired function of tissue-resident multipotent cells play role in …

Diabetic cardiomyopathy: 2023 update by the international multidisciplinary board of experts

A Avagimyan, F Fogacci, N Pogosova… - Current Problems in …, 2023 - Elsevier
Diabetes mellitus (DM) is considered by many the pandemic of the 21st century and is
associated with multiple organ damages. Among these, cardiovascular complications are …