Mitochondrial control of inflammation
Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …
associated molecular patterns (DAMPs) and promote inflammation when released into the …
Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Randomized trial of metformin, ivermectin, and fluvoxamine for Covid-19
Background Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an
important component of the comprehensive response to the severe acute respiratory …
important component of the comprehensive response to the severe acute respiratory …
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
LK Billingham, JS Stoolman, K Vasan… - Nature …, 2022 - nature.com
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …
SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …
particular risk for severe disease and death in older adults and in adults with age-related …
Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury
Z Liu, M Wang, X Wang, Q Bu, Q Wang, W Su, L Li… - Redox Biology, 2022 - Elsevier
Hepatocellular cell death and macrophage proinflammatory activation contribute to the
pathology of various liver diseases, during which XBP1 plays an important role. However …
pathology of various liver diseases, during which XBP1 plays an important role. However …
Mitochondrial DNA release in innate immune signaling
According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …
[HTML][HTML] Oxidized DNA fragments exit mitochondria via mPTP-and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
H Xian, K Watari, E Sanchez-Lopez, J Offenberger… - Immunity, 2022 - cell.com
Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …