Cells reprogram gene expression in response to environmental changes by mobilizing
transcriptional activators. The activator protein Gcn4 of the yeast Saccharomyces cerevisiae …

The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest
due to its involvement in a large array of crucial biological processes. Some of these are …

A systematic computational analysis of protein sequences containing known nuclear
domains led to the identification of 28 novel domain families. This represents a 26 …

Protein kinase GCN2 regulates translation in amino acid–starved cells by phosphorylating
eIF2. GCN2 contains a regulatory domain related to histidyl-tRNA synthetase (HisRS) …

Protein synthesis is the ultimate step of gene expression and a key control point for
regulation. In particular, it enables cells to rapidly manipulate protein production without new …

The GCN2 eIF2α kinase is essential for activation of the general amino acid control pathway
in yeast when one or more amino acids become limiting for growth. GCN2's function in …

A family of protein kinases regulates translation in response to different cellular stresses by
phosphorylation of the α subunit of eukaryotic initiation factor-2 (eIF-2α). In yeast, an eIF-2α …

In eukaryotic cells, protein synthesis is regulated in response to various environmental
stresses by phosphorylating the α subunit of the eukaryotic initiation factor 2 (eIF2α). Three …

Transcriptional and translational feedback loops in fungi and animals drive circadian
rhythms in transcript levels that provide output from the clock, but post-transcriptional …

Protein production must be strictly controlled at its beginning and end to synthesize a
polypeptide that faithfully copies genetic information carried in the encoding mRNA. In …