The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

The presence and reactivation of chronic viral infections such as Epstein-Barr virus (EBV),
cytomegalovirus (CMV) and human immunodeficiency virus (HIV) have been proposed as …

Greater numbers of individuals are living to older ages. A major concern at both individual
and population levels is how to live these years at a high functional level. If we had …

Human cytomegalovirus (HCMV) is a herpes virus that infects and is carried by 70–100% of
the world's population. During its evolution, this virus has developed mechanisms that allow …

Accumulating data are documenting an inverse relationship between immune status,
response to vaccination, health, and longevity, suggesting that the immune system becomes …

In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of
high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated …

Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most
striking consequences of immunosenescence, as it is believed to be linked to the majority of …

Morbidity and mortality due to infectious disease is greater in the elderly than in the young,
at least partly because of age‐associated decreased immune competence, which renders …

Mature T cells are produced in the thymus and released into the bloodstream in low
numbers. These cells are considered to be immunologically naıve until such time as they …

Cytomegalovirus (CMV) is a common herpesvirus infection and stimulates the expansion of
very large numbers of CMV‐specific T cells that reduce the CD 4/CD 8 ratio and suppress …