The number of people over the age of 60 is expected to double by 2050 according to the
WHO. This emphasizes the need to ensure optimized resilience to health stressors in late …

The mammalian immune system defends the organism against pathogens, and possibly
cancer, but is known to become dysregulated with increasing age. This results in greater …

Geriatric oncology, important for the ever-increasing numbers of elderly cancer patients, has
thus far focused primarily on tolerance to chemotherapy. With the advent of breakthrough …

Neuroinflammation is considered a chronic activation of the immune response in the central
nervous system (CNS) in response to different injuries. This brain immune activation results …

Poor sleep quality and short sleep duration are associated with increased incidence and
progression of a number of chronic health conditions observed at greater frequency among …

Methods The SEC sample came from the six most populous provinces of Cambodia, which
combined included more than 50% of the national population. These were, in the order of …

The increased life expectancy and the expansion of the elderly population are stimulating
research into aging. Aging may be viewed as a multifactorial process that results from the …

Abstract Background. A low CD4/CD8 ratio in human immunodeficiency virus (HIV)–infected
individuals despite effective antiretroviral therapy (ART) reflects ongoing immune activation …

Immunological changes associated with aging play a major role in both the blunted
responses to infections as well as to vaccines intended to prevent many of these infections …

Latent herpesvirus infections alter immune homeostasis. To understand if this results in
aging-related loss of immune protection against emerging infections, we challenged old …