Childhood abuse confers risk for psychopathology and pathophysiology in midlife through
intermediate pathways that remain unclear. Systemic inflammation was tested in the present …

Maltreatment and trauma in childhood, termed early-life stress (ELS), has long-term effects
on the immune system. ELS impacts immune signaling at the time of exposure but also …

Objectives.—Migraine is a risk factor for stroke in young women. Biomarker studies implicate
endothelial activation as a possible mechanism. Emerging relationships of childhood …

Background: The situation in the world today, encompassing multiple armed conflicts,
notably in Ukraine, the Coronavirus pandemic and the effects of climate change, increases …

Objective: To examine the relationship of recalled adverse childhood experiences (ACEs)
with migraine and episodic tension-type headache (ETTH). Methods: We conducted a cross …

Depression is the most common mental disorder and has become a heavy burden in
modern society. Clinical studies have identified early life stress as one of the high-risk …

Early-life adversity affects long-term health outcomes but there is considerable
interindividual variability in susceptibility to environmental influences. We proposed that …

Prior research has found inconsistent evidence regarding the association among childhood
adversity, inflammation, and internalizing symptoms, perhaps because previous studies …

The biological embedding model (BEM) suggests that fitness costs of maternal loss arise
when early-life experience embeds long-term alterations to hypothalamic-pituitary-adrenal …

Background This pilot study examined whether breast cancer patients with childhood trauma
exhibit increased fatigue, depression, and stress in association with inflammation as a result …