3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely
used for the treatment of hypercholesterolemia. Their efficacy in preventing cardiovascular …

Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible
for the metabolism of about 60% of currently known drugs. However, this unusual low …

Pitavastatin, a novel potent 3-hydroxymethylglutaryl-CoA reductase inhibitor, is selectively
distributed to the liver in rats. However, the hepatic uptake mechanism of pitavastatin has not …

The unprecedented advances in molecular biology during the last two decades have
resulted in a dramatic increase in knowledge about gene structure and function, an …

A resurgence in the use of medical herbs in the Western world, and the co-use of modern
and traditional therapies is becoming more common. Thus there is the potential for both …

The contributions of specific human liver cytochrome P-450 (CYP) enzymes to the activation,
via 4-hydroxylation, of the oxazaphosphorine anticancer prodrugs cyclophosphamide (CPA) …

Because of their unique effects and relatively low side effects, herbal medicine has been
gaining popularity all over the world. Quality control is a challenge to ensure safety, efficacy …

The cytochromes P450 (CYPs) constitute a superfamily of hemoprotein enzymes that are
responsible for the biotransformation of numerous xenobiotics, including therapeutic agents …

We demonstrate here that Chinese hamster ovary cells stably expressing PRL-3, a M r
20,000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced …

The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means
of predicting potential drug-drug interactions, have not yet been investigated. The objective …