The roles of androgens in humans: biology, metabolic regulation and health

M Alemany - International journal of molecular sciences, 2022 - mdpi.com
Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Andropause: clinical implications of the decline in serum testosterone levels with aging in men

AM Matsumoto - The Journals of Gerontology Series A …, 2002 - academic.oup.com
T is now well accepted that serum testosterone (T) levels decline progressively with aging in
men (1–5). This decline is associated with alterations in body composition; diminished …

Doping with anabolic androgenic steroids (AAS): Adverse effects on non-reproductive organs and functions

E Nieschlag, E Vorona - Reviews in Endocrine and Metabolic Disorders, 2015 - Springer
Since the 1970s anabolic androgenic steroids (AAS) have been abused at ever increasing
rates in competitive athletics, in recreational sports and in bodybuilding. Exceedingly high …

Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial

HG Pope Jr, GH Cohane, G Kanayama… - American Journal of …, 2003 - Am Psychiatric Assoc
OBJECTIVE: Testosterone supplementation may produce antidepressant effects in men, but
until recently it has required cumbersome parenteral administration. In an 8-week …

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men

N Gharahdaghi, S Rudrappa, MS Brook… - Journal of Cachexia …, 2019 - Wiley Online Library
Background The andropause is associated with declines in serum testosterone (T), loss of
muscle mass (sarcopenia), and frailty. Two major interventions purported to offset …

Low testosterone levels are associated with coronary artery disease in male patients with angina

GMC Rosano, I Sheiban, R Massaro… - International Journal of …, 2007 - nature.com
Historically, high androgen levels have been linked with an increased risk for coronary
artery disease (CAD). However, more recent data suggest that low androgen levels are …

[HTML][HTML] Growing older with health and vitality: a nexus of physical activity, exercise and nutrition

OC Witard, C McGlory, DL Hamilton, SM Phillips - Biogerontology, 2016 - Springer
The preservation of skeletal muscle mass and strength with advancing age are, we propose,
critical aspects of ageing with health and vitality. Physical inactivity and poor nutrition are …

A satellite cell‐specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle

V Dubois, MR Laurent, M Sinnesael… - The FASEB …, 2014 - Wiley Online Library
Androgens have well‐established anabolic actions on skeletal muscle, although the direct
effects of the androgen receptor (AR) in muscle remain unclear. We generated satellite cell …

Psychiatric side effects induced by supraphysiological doses of combinations of anabolic steroids correlate to the severity of abuse

TA Pagonis, NV Angelopoulos, GN Koukoulis… - European …, 2006 - cambridge.org
ObjectiveThe objective of our study was to evaluate the psychological consequences of real-
world AAS use in athletes abusing such agents, in comparison with a placebo and control …

Skeletal muscle function in COPD

R Casaburi - Chest, 2000 - Elsevier
Few effective therapies exist for patients with COPD. Rehabilitative therapy aimed at curing
dysfunction of the peripheral muscles may be an appropriate addition to this short list. This …