[PDF][PDF] 15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
The functional and evolutionary impacts of human-specific deletions in conserved elements
Conserved genomic sequences disrupted in humans may underlie uniquely human
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
Interpreting population-and family-based genome-wide association studies in the presence of confounding
A central aim of genome-wide association studies (GWASs) is to estimate direct genetic
effects: the causal effects on an individual's phenotype of the alleles that they carry …
effects: the causal effects on an individual's phenotype of the alleles that they carry …
The impact of rare protein coding genetic variation on adult cognitive function
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology
CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
DNA methylation provides a crucial epigenetic mark linking genetic variations to
environmental influence. We have analyzed array-based DNA methylation profiles of 160 …
environmental influence. We have analyzed array-based DNA methylation profiles of 160 …
[HTML][HTML] Restoring the missing person to personalized medicine and precision psychiatry
Precision psychiatry has emerged as part of the shift to personalized medicine and builds on
frameworks such as the US National Institute of Mental Health Research Domain Criteria …
frameworks such as the US National Institute of Mental Health Research Domain Criteria …
Celebrating a century of research in behavioral genetics
R Plomin - Behavior Genetics, 2023 - Springer
A century after the first twin and adoption studies of behavior in the 1920s, this review looks
back on the journey and celebrates milestones in behavioral genetic research. After a …
back on the journey and celebrates milestones in behavioral genetic research. After a …
Persistent thinness and anorexia nervosa differ on a genomic level
Thinness and anorexia nervosa are both characterised by persistent low weight. Individuals
with anorexia nervosa concurrently report distorted perceptions of their body and engage in …
with anorexia nervosa concurrently report distorted perceptions of their body and engage in …