Depressive disorders are among the leading causes of global disease burden, but there has
been limited progress in understanding the causes of and treatments for these disorders. In …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Despite decades of clinical, sociopolitical, and research efforts, progress in understanding
and treating mental health problems remains disappointing. I discuss two barriers that have …

The p-factor is a construct that is thought to explain and maybe even cause variation in all
forms of psychopathology. Since its 'discovery'in 2012, hundreds of studies have been …

The network theory of psychopathology posits that mental disorders are complex systems of
mutually reinforcing symptoms. This overarching framework has proven highly generative …

Identifying the different influences of symptoms in dynamic psychopathology models may
hold promise for increasing treatment efficacy in clinical applications. Dynamic …

Background: In a recent clinical trial examining the comparative efficacy of psilocybin
therapy (PT) versus escitalopram treatment (ET) for major depressive disorder, 14 of 16 …

Models and theories in behaviour change science are not in short supply, but they almost
exclusively pertain to a particular facet of behaviour, such as automaticity or reasoned …

Background Predicting future states of psychopathology such as depressive episodes has
been a hallmark initiative in mental health research. Dynamical systems theory has …

Method As examples of the new approaches that have emerged, here we introduce the
Hierarchical Taxonomy of Psychopathology (HiTOP), the Research Domain Criteria (RDoC) …