Research progress and applications of nanobody in human infectious diseases

Y Mei, Y Chen, JP Sivaccumar, Z An, N Xia… - Frontiers in …, 2022 - frontiersin.org
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises.
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …

miR-204–containing exosomes ameliorate GVHD-associated dry eye disease

T Zhou, C He, P Lai, Z Yang, Y Liu, H Xu, X Lin, B Ni… - Science …, 2022 - science.org
Graft-versus-host disease (GVHD)–associated dry eye disease is characterized by extensive
inflammatory destruction in the ocular surface and causes unbearable pain and visual …

Animal model of severe fever with thrombocytopenia syndrome virus infection

J Sun, YQ Min, Y Li, X Sun, F Deng, H Wang… - Frontiers in …, 2022 - frontiersin.org
Severe fever with thrombocytopenia syndrome (SFTS), an emerging life-threatening
infectious disease caused by SFTS bunyavirus (SFTSV; genus Bandavirus, family …

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

X Wu, L Cheng, M Fu, B Huang, L Zhu, S Xu, H Shi… - Cell reports, 2021 - cell.com
The dramatically expanding coronavirus disease 2019 (COVID-19) needs multiple effective
countermeasures. Neutralizing nanobodies (Nbs) are a potential therapeutic strategy for …

Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein

Q Lu, Z Zhang, H Li, K Zhong, Q Zhao, Z Wang… - Journal of …, 2021 - Springer
Background The outbreak and pandemic of coronavirus SARS-CoV-2 caused significant
threaten to global public health and economic consequences. It is extremely urgent that …

AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia

W Nawaz, B Huang, S Xu, Y Li, L Zhu, H Yiqiao… - Blood cancer …, 2021 - nature.com
Chimeric antigen receptor (CAR) T-cell therapy is the most active field in immuno-oncology
and brings substantial benefit to patients with B cell malignancies. However, the complex …

Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics

W Alata, A Yogi, E Brunette, CE Delaney… - The FASEB …, 2022 - Wiley Online Library
The blood‐brain barrier (BBB) prevents the majority of drugs from crossing into the brain and
reaching neurons. To overcome this challenge, safe and non‐invasive technologies …

[HTML][HTML] Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway

YH Li, XH Wang, WW Huang, RR Tian, W Pang… - Redox Biology, 2023 - Elsevier
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious
disease caused by the SFTS virus (SFTSV) and with a high fatality rate. Thrombocytopenia …

Bunyavirales: scientific gaps and prototype pathogens for a large and diverse group of zoonotic viruses

AL Hartman, PJ Myler - The Journal of Infectious Diseases, 2023 - academic.oup.com
Research directed at select prototype pathogens is part of the approach put forth by the
National Institute of Allergy and Infectious Disease (NIAID) to prepare for future pandemics …

Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome

S Xu, N Jiang, W Nawaz, B Liu, F Zhang, Y Liu… - PLoS …, 2021 - journals.plos.org
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne emerging
phlebovirus with high mortality rates of 6.0 to 30%. SFTSV infection is characterized by high …