RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

Following the Ebola virus disease epidemic in west Africa, there has been increased
awareness of the need for improved therapies for emerging diseases, including viral …

Members of the family Filoviridae produce variously shaped, often filamentous, enveloped
virions containing linear non-segmented, negative-sense RNA genomes of 15–19 kb …

Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

Abstract The West Africa Ebola outbreak was the largest outbreak ever recorded, with over
28,000 reported infections; this devastating epidemic emphasized the need to understand …

Abstract Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe
respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a …

Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs)
located in the perinuclear region. The formation of these IBs is induced mainly by the …

The aggregation of amyloidogenic proteins is a pathological hallmark of various
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and …

Cryo-electron microscopy (CryoEM) has superseded X-ray crystallography and NMR to
emerge as a popular and effective tool for structure determination in recent times. It has …

Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to
organize intracellular membrane-less structures. Studies with non-segmented negative …