A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2
H Yao, H Cai, T Li, B Zhou, W Qin, D Lavillette… - PLoS …, 2021 - journals.plos.org
A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding
domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the …
domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the …
[HTML][HTML] Flexible, functional, and familiar: characteristics of SARS-CoV-2 spike protein evolution
The SARS-CoV-2 S protein is a major point of interaction between the virus and the human
immune system. As a consequence, the S protein is not a static target but undergoes rapid …
immune system. As a consequence, the S protein is not a static target but undergoes rapid …
COVID‐19 vaccines: knowing the unknown
Vaccine development against SARS‐CoV‐2 has drawn attention around the globe due to
the exploding pandemic. Although COVID‐19 is caused by a new coronavirus, SARS‐CoV …
the exploding pandemic. Although COVID‐19 is caused by a new coronavirus, SARS‐CoV …
Perspectives on the development of neutralizing antibodies against SARS-CoV-2
M Ho - Antibody therapeutics, 2020 - academic.oup.com
SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-
converting enzyme 2 (ACE2). Therefore, the receptor binding domain (RBD) of the S protein …
converting enzyme 2 (ACE2). Therefore, the receptor binding domain (RBD) of the S protein …
Mechanisms of dysregulated humoral and cellular immunity by SARS-CoV-2
The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe
acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December …
acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December …
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody
T Li, H Cai, Y Zhao, Y Li, Y Lai, H Yao… - EMBO Molecular …, 2021 - embopress.org
An essential step for SARS‐CoV‐2 infection is the attachment to the host cell receptor by its
Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing …
Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing …
[HTML][HTML] Structural classification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain suggests vaccine and therapeutic strategies
The COVID-19 pandemic presents an urgent health crisis. Human neutralizing antibodies
(hNAbs) that target the host ACE2 receptor-binding domain (RBD) of the SARS-CoV-2 spike …
(hNAbs) that target the host ACE2 receptor-binding domain (RBD) of the SARS-CoV-2 spike …
Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2
SA Lim, JA Gramespacher, K Pance, NJ Rettko… - MAbs, 2021 - Taylor & Francis
Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most
directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin …
directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin …
[HTML][HTML] Structural basis of a public antibody response to SARS-CoV-2
Molecular-level understanding of human neutralizing antibody responses to SARS-CoV-2
could accelerate vaccine design and facilitate drug discovery. We analyzed 294 SARS-CoV …
could accelerate vaccine design and facilitate drug discovery. We analyzed 294 SARS-CoV …
[HTML][HTML] Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization
In vitro antibody selection against pathogens from naïve combinatorial libraries can yield
various classes of antigen-specific binders that are distinct from those evolved from natural …
various classes of antigen-specific binders that are distinct from those evolved from natural …