Designing spatial and temporal control of vaccine responses

GA Roth, VCTM Picece, BS Ou, W Luo… - Nature Reviews …, 2022 - nature.com
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Recent advances in hyperthermia therapy‐based synergistic immunotherapy

M Chang, Z Hou, M Wang, C Li, J Lin - Advanced Materials, 2021 - Wiley Online Library
The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy
against malignant tumors. Nanomaterial‐based photothermal therapy (PTT) and magnetic …

γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis

C Junqueira, RB Polidoro, G Castro, S Absalon… - Nature …, 2021 - nature.com
Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are
expanded in Plasmodium falciparum–infected patients. Although previous studies …

Antibodies against Plasmodium falciparum malaria at the molecular level

JP Julien, H Wardemann - Nature Reviews Immunology, 2019 - nature.com
Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …

Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets

NL Dooley, TG Chabikwa, Z Pava… - Nature …, 2023 - nature.com
Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Five decades of clinical assessment of whole-sporozoite malaria vaccines

H Nunes-Cabaço, D Moita, M Prudêncio - Frontiers in Immunology, 2022 - frontiersin.org
In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype

R Guha, A Mathioudaki, S Doumbo, D Doumtabe… - PLoS …, 2021 - journals.plos.org
In malaria-naïve children and adults, Plasmodium falciparum-infected red blood cells (Pf-
iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic …

Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …