Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …

Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …

From a structural perspective, the predominant glial cell of the central nervous system, the
astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the …

1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor,
schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies …

Schizophrenia is a severe mental disorder associated with a characteristic constellation of
symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively …

BACKGROUND: Glutamate has been thought to have a role in mental disorders. Because
the postmortem interval (PMI) has such a pronounced effect on glutamate and other amino …