Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

Polycystic ovary syndrome (PCOS) is a one of the most common endocrine disorders, with a
prevalence rate of 5–10% in reproductive aged women. It's characterized by (1) chronic …

White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …