Ultraviolet B regulation of transcription factor families: Roles of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis
SJ Cooper, GT Bowden - Current cancer drug targets, 2007 - ingentaconnect.com
Prolonged and repeated exposure of the skin to ultraviolet light (UV) leads not only to aging
of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage …
of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage …
Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
Genotoxic stress in mammalian cells, including those caused by anti-cancer chemotherapy,
can induce temporary cell-cycle arrest, DNA damage-induced senescence (DDIS), or …
can induce temporary cell-cycle arrest, DNA damage-induced senescence (DDIS), or …
Tumour necrosis factor α induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor κB and activator protein-1
GSH synthesis occurs via two enzymatic steps catalysed by GCL [glutamate–cysteine ligase,
made up of GCLC (GCL catalytic subunit), and GCLM (GCL modifier subunit)] and GSS …
made up of GCLC (GCL catalytic subunit), and GCLM (GCL modifier subunit)] and GSS …
Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene
PR Manna, DW Eubank, DM Stocco - Molecular Endocrinology, 2004 - academic.oup.com
Abstract cAMP-dependent mechanisms regulate the steroidogenic acute regulatory (StAR)
protein even though its promoter lacks a consensus cAMP response-element (CRE …
protein even though its promoter lacks a consensus cAMP response-element (CRE …
A preliminary operational classification system for nonmutagenic modes of action for carcinogenesis
D Hattis, M Chu, N Rahmioglu, R Goble… - Critical reviews in …, 2009 - Taylor & Francis
This article proposes a system of categories for nonmutagenic modes of action for
carcinogenesis. The classification is of modes of action rather than individual carcinogens …
carcinogenesis. The classification is of modes of action rather than individual carcinogens …
[HTML][HTML] JNK-dependent phosphorylation of c-Jun on serine 63 mediates nitric oxide-induced apoptosis of neuroblastoma cells
L Li, Z Feng, AG Porter - Journal of Biological Chemistry, 2004 - ASBMB
c-Jun NH 2-terminal kinases (JNKs) potentiate transcriptional activity of c-Jun by
phosphorylating serines 63 and 73. Moreover, JNK and c-Jun can modulate apoptosis …
phosphorylating serines 63 and 73. Moreover, JNK and c-Jun can modulate apoptosis …
The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein
Sex-determining region Y-box 2 (SOX2), a well-known stemness biomarker, is highly
expressed in a variety of cancers, including human highly invasive bladder cancer (BC) …
expressed in a variety of cancers, including human highly invasive bladder cancer (BC) …
Activator protein-1 activity regulates epithelial tumor cell identity
To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in
skin, transgenic mice were generated, which use the tetracycline system to conditionally …
skin, transgenic mice were generated, which use the tetracycline system to conditionally …
[HTML][HTML] Activation of the Interleukin-6 promoter by a dominant negative mutant of c-Jun
L Faggioli, C Costanzo, M Donadelli… - Biochimica et Biophysica …, 2004 - Elsevier
The human IL-6 promoter contains multiple regulatory elements such as those binding
transcription factors belonging to the NF-κB (− 75/− 63), C/EBP (− 158/− 145 and− 87/− 76) …
transcription factors belonging to the NF-κB (− 75/− 63), C/EBP (− 158/− 145 and− 87/− 76) …
The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate …
Y Pan, JS Zhang, MH Gazi, CYF Young - Cancer Epidemiology Biomarkers & …, 2003 - AACR
Nonsteroidal anti-inflammatory drugs (NSAIDs) play potential roles in cancer
chemoprevention. In this study, we investigated the effects of NSAIDs on androgen receptor …
chemoprevention. In this study, we investigated the effects of NSAIDs on androgen receptor …