The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

Background The primary goal of radiotherapy (RT) is to induce cellular damage on
malignant cells; however, it is becoming increasingly recognized the important role played …

Older patients with cancer, particularly those over 75 years of age, often experience poorer
clinical outcomes compared to younger patients. This can be attributed to age-related …

The involvement of cellular senescence in the initiation and propagation of diseases is
clearly characterized, making the elimination of senescent cells essential to treat age-related …

Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in
normal tissue turnover and is associated with a variety of age-related diseases, including …

Human health requires homeostasis and coherence to respond to stress and synchronize
physiological functions. This state of balance is gradually lost during aging when senescent …

Cellular senescence is characterized by the permanent arrest of cell proliferation and is a
response to endogenous and exogenous stress. The continuous accumulation of senescent …

Aging is a pathophysiological process that causes a gradual and permanent reduction in all
biological system functions. The phenomenon is caused by the accumulation of …

Fibrosing interstitial lung diseases (ILDs) are characterized by the gradual and irreversible
accumulation of scar tissue in the lung parenchyma. The role of the immune response in the …

Immunosenescence is a process of immune system remodeling based on the natural aging
process. Factors such as diet, physical exercise, mental health, and genetic/metabolic …