Gathering brings strength: How organic aggregates boost disease phototheranostics

J Qi, H Ou, Q Liu, D Ding - Aggregate, 2021 - Wiley Online Library
Phototheranostics that concurrently and complementarily integrate real‐time diagnosis and
in situ therapeutic capabilities in one platform has become the advancing edge of precision …

Artificial intelligence in cardiology

KW Johnson, J Torres Soto, BS Glicksberg… - Journal of the American …, 2018 - jacc.org
Artificial intelligence and machine learning are poised to influence nearly every aspect of the
human condition, and cardiology is not an exception to this trend. This paper provides a …

The 'Digital Twin'to enable the vision of precision cardiology

J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Biomarker definitions and their applications

RM Califf - Experimental biology and medicine, 2018 - journals.sagepub.com
Biomarkers are critical to the rational development of medical therapeutics, but significant
confusion persists regarding fundamental definitions and concepts involved in their use in …

Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial

GA Lewis, S Dodd, D Clayton, E Bedson, H Eccleson… - Nature Medicine, 2021 - nature.com
In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial
fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent …

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

A Levin, M Tonelli, J Bonventre, J Coresh, JA Donner… - The Lancet, 2017 - thelancet.com
The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …

Targeting cardiovascular inflammation: next steps in clinical translation

PR Lawler, DL Bhatt, LC Godoy… - European heart …, 2021 - academic.oup.com
Systemic vascular inflammation plays multiple maladaptive roles which contribute to the
progression and destabilization of atherosclerotic cardiovascular disease (ASCVD). These …

Network-based approach to prediction and population-based validation of in silico drug repurposing

F Cheng, RJ Desai, DE Handy, R Wang… - Nature …, 2018 - nature.com
Here we identify hundreds of new drug-disease associations for over 900 FDA-approved
drugs by quantifying the network proximity of disease genes and drug targets in the human …

Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Digital health technology and mobile devices for the management of diabetes mellitus: state of the art

R Shan, S Sarkar, SS Martin - Diabetologia, 2019 - Springer
Diabetes mellitus is a disease that can be difficult to manage and requires high levels of
health literacy and numeracy, self-monitoring and frequent contact with clinicians. If not …