Macrophages (MΦs) are the most abundant leukocytes in mammalian ovaries that have
heterogeneity and plasticity. A body of evidence has indicated that these cells are important …

Uterine aging is the process of the senescence of uterine tissue, observed in all middle-
aged mammals. Since the aging-related changes in the uterus are associated with infertility …

The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

The concept of dedifferentiation and reprogramming of mature somatic cells holds much
promise for the three-front “war” against tissue damage, cancer, and aging. It was hoped that …

The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased
collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex …

The ovary is indispensable for female reproduction, and its age-dependent functional
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …

Anti-aging strategies extend beyond cosmetic concerns, reaching into the realm of disease
prevention, promoting longevity, and optimizing overall health. The quest for a longer …

With the increase in the age of laying chickens, the aging of follicles is accelerated, and the
reproductive ability is decreased. Increased oxidative stress and mitochondrial malfunction …

Ovarian aging is a major obstacle in assisted reproductive medicine because it leads to
ovarian dysfunction in women of advanced age. Currently, there are no effective treatments …