Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to
SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2) …

We have previously provided the first genetic evidence that angiotensin converting enzyme
2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS …

The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Macrophages have important roles in immune surveillance and in the maintenance of
kidney homeostasis; their response to renal injury varies enormously depending on the …

During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …

Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …