Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Inflammaging and osteoarthritis

F Motta, E Barone, A Sica, C Selmi - Clinical Reviews in Allergy & …, 2023 - Springer
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Obesity and bone: a complex relationship

G Rinonapoli, V Pace, C Ruggiero, P Ceccarini… - International journal of …, 2021 - mdpi.com
There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …

[HTML][HTML] The burden of OA-health services and economics

VP Leifer, JN Katz, E Losina - Osteoarthritis and cartilage, 2022 - Elsevier
Osteoarthritis (OA) is a highly prevalent and disabling condition that affects over 7% of
people globally (528 million people). Prevalence levels are even higher in countries with …

Epidemiology of osteoarthritis: literature update

ER Vina, CK Kwoh - Current opinion in rheumatology, 2018 - journals.lww.com
Epidemiology of osteoarthritis: literature update : Current Opinion in Rheumatology
Epidemiology of osteoarthritis: literature update : Current Opinion in Rheumatology Log in or …

Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation

GA Bray, KK Kim, JPH Wilding… - Obesity …, 2017 - Wiley Online Library
This paper considers the argument for obesity as a chronic relapsing disease process.
Obesity is viewed from an epidemiological model, with an agent affecting the host and …

The burden of osteoarthritis in older adults

GA Hawker, LK King - Clinics in geriatric medicine, 2022 - geriatric.theclinics.com
Osteoarthritis (OA) is a serious disease. The most common form of arthritis, 1 OA typically
affects the hips, knees, hands, feet, and spine, and multijoint involvement is common. 2 OA …

Intestinal microbiome composition and its relation to joint pain and inflammation

CG Boer, D Radjabzadeh, C Medina-Gomez… - Nature …, 2019 - nature.com
Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related
pain and severity, and has been suggested to be triggered by endotoxins produced by the …

[HTML][HTML] Osteoarthritis year in review 2017: clinical

AE Nelson - Osteoarthritis and cartilage, 2018 - Elsevier
This review is based on a systematic review of the literature relevant to clinical topics in
osteoarthritis (OA) performed for the time period February 22, 2016 to April 1, 2017. A …