The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …

Immunity to viruses requires an array of critical cellular proteins that include IFN regulatory
factor 3 (IRF3). Consequently, most viruses that infect vertebrates encode proteins that …

Malaria, which results from infection with Plasmodium parasites, remains a major public
health problem. Although humans do not develop long-lived, sterilizing immunity, protection …

Malaria is a major global health problem. Despite decades of research, there is still no
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …

The dynamics of CD4+ T cell memory development remain to be examined at genome
scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its …

A single exposure to many viral and bacterial pathogens typically induces life-long immunity,
however, the development of the protective immunity to Plasmodium parasites is strikingly …

Innate lymphoid cells (ILC) are similar to T helper (Th) cells in expression of cytokines and
transcription factors. For example, RORγt is the lineage-specific transcription factor for both …

Type I interferons (IFNs) are a family of cytokines with a wide range of biological activities
including anti‐viral and immune‐regulatory functions. Here, we focus on the protozoan …