Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

The zebrafish is a powerful model system for studying animal development, for modeling
genetic diseases, and for large-scale in vivo functional genetics. Because of its ease of use …

Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal
neuron degeneration in Parkinson's disease (PD). Several studies in experimental models …

The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …

To enable rapid propagation of action potentials, axons are ensheathed by myelin, a
multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is …

Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

CRISPR-Cas9 can be scaled up for large-scale screens in cultured cells, but CRISPR
screens in animals have been challenging because generating, validating, and keeping …

Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages
that control post-injury inflammation. However, the mechanistic basis of how macrophages …

Bicuspid aortic valve (BAV), the most common cardiovascular malformation occurs in 0.5–
1.2% of the population. Although highly heritable, few causal mutations have been identified …

Many types of differentiated cells can reenter the cell cycle upon injury or stress. The
underlying mechanisms are still poorly understood. Here, we investigated how quiescent …