Fms-like tyrosine kinase 3 (FLT3) is an important member of the class III receptor tyrosine
kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and …

Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common
genetic abnormalities detected in about 30% of acute myeloid leukemia (AML) patients …

African trypanosomiasis, sleeping sickness in humans or nagana in animals, is a potentially
fatal neglected tropical disease and a threat to 65 million human lives and 100 million small …

This work is focused on the synthesis and characterization by spectroscopic methods of new
indazole compounds containing carboxamide and acetamido N-substituted moieties on C 3 …

Novel tolfenamic acid derivatives based on the structure of I-1 were designed and
synthesized to improve its poor target inhibition and solubility. Among them, W10 was …

A palladium-catalyzed carbonylative cyclization of 2-ethynylanilines with nitroarenes has
been developed for the rapid synthesis of indole-3-carboxamide skeletons. By using …

Chemoselective copper-catalyzed synthesis of diverse N-arylindole-3-carboxamides, β-oxo
amides and N-arylindole-3-carbonitriles from readily accessible indole-3-carbonitriles, α …

Promiscuity is an interesting concept in fragment‐based drug design as fragments with low
specificity can be advantageous for finding many screening hits. We present a PDB‐wide …

摘要报道了邻氨基苯乙酰胺和邻氨基苯乙酸酯在重氮化试剂作用下直接转化为对应的1H-吲唑-3-
羧酸衍生物. 该反应操作简单, 反应条件温和, 反应迅速, 产率高, 底物范围广, 为1H-吲唑-3 …

Direct conversion of ortho-aminobenzacetamides and ortho-aminobenzacetates to the
corresponding 1H-indazole-3-carboxylic acid derivatives under the action of diazotization …