Playing Hide-and-Seek with Tyrosine Kinase Inhibitors: Can We Overcome Administration Challenges?
S Kollipara, M Chougule, R Boddu, A Bhatia… - The AAPS Journal, 2024 - Springer
Tyrosine kinase inhibitors (TKIs) have demonstrated significant efficacy against various
types of cancers through molecular targeting mechanisms. Over the past 22 years, more …
types of cancers through molecular targeting mechanisms. Over the past 22 years, more …
Dissolution Profiles Comparison Using Conventional and Bias Corrected and Accelerated f2 Bootstrap Approaches with Different Software's: Impact of Variability …
R Boddu, S Kollipara, AK Bhattiprolu, K Parsa… - AAPS …, 2023 - Springer
Dissolution profiles comparison is an important element in order to support biowaivers, scale-
up and post approval changes and site transfers. Highly variable dissolution can possess …
up and post approval changes and site transfers. Highly variable dissolution can possess …
Novel application of PBBM to justify impact of faster dissolution on safety and pharmacokinetics–a case study and utility in regulatory justifications
R Boddu, S Kollipara, AK Bhattiprolu, T Ahmed - Xenobiotica, 2023 - Taylor & Francis
Physiologically based biopharmaceutics modelling (PBBM) was recognised as potential
approach for biopharmaceutics applications. However, PBBM to justify safety is an …
approach for biopharmaceutics applications. However, PBBM to justify safety is an …
[PDF][PDF] Experience on Utilization of Novel Modeling & Simulation Approaches in Generic Product Development
R Boddu, S Kollipara, A Rachapally, T Ahmed - Journal ISSN, 2024 - jelsciences.com
Modeling and simulation approaches such as Physiologically Based Pharmacokinetic
(PBPK) and Physiologically Based Biopharmaceutics Modeling (PBBM) are gaining …
(PBPK) and Physiologically Based Biopharmaceutics Modeling (PBBM) are gaining …