The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

Spatial transcriptomics technologies enable researchers to accurately quantify and localize
messenger ribonucleic acid (mRNA) transcripts at a high resolution while preserving their …

A key challenge of analyzing data from high-resolution spatial profiling technologies is to
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …

Spatial transcriptomics (ST) is a newly emerging field that integrates high-resolution imaging
and transcriptomic data to enable the high-throughput analysis of the spatial localization of …

In this Perspective, we discuss the current status and advances in spatial transcriptomics
technologies, which allow high-resolution mapping of gene expression in intact cell and …

Background and objectives Spatially resolved techniques for exploring the molecular
landscape of tissue samples, such as spatial transcriptomics, often result in millions of data …

Background The emergence of high-resolved spatial transcriptomics (ST) has facilitated the
research of novel methods to investigate biological development, organism growth, and …

Data visualization empowers researchers to communicate their results that support scientific
reasoning in an intuitive way. Three-dimension (3D) spatially resolved transcriptomic atlases …

Neural circuits are characterized as interconnecting neuron networks connected by
synapses. Some kinds of gene expression and/or functional changes of neurons and …

Highlights•Spatial omics provide multi-layer molecular profiling of cancer with high
resolution.•mIHC/IF and spatial transcriptomics techniques are advancing immunotherapy.• …