The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

Inflammation plays a role in the initiation and development of many types of cancers,
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …

The fibroblastic element of the tumor microenvironment has been of great interest to cancer
biologists but less so to cancer immunologists. Yet, the sharing of a common mesenchymal …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Metastasis of cancer cells is a complex process involving multiple steps including invasion,
angiogenesis, and trafficking of cancer cells through blood vessels, extravasations, organ …

Despite considerable efforts to improve early detection, and advances in chemotherapy,
metastasis remains a major challenge in the clinical management of ovarian cancer. Studies …

Breast cancer is one of the leading causes of cancer related deaths worldwide. Breast
cancer-related mortality is associated with the development of metastatic potential of primary …

Hematopoietic and epithelial cancer cells express CXCR4, a seven-transmembrane G-
protein-coupled chemokine receptor. Stromal cells within the bone marrow …