Abstract G-quadruplex (G4) structural motifs have been linked to transcription 1, 2,
replication 3 and genome instability 4, 5 and are implicated in cancer and other diseases 6 …

Single-cell ATAC-seq (scATAC) yields sparse data that make conventional analysis
challenging. We developed chromVAR (http://www. github. com/GreenleafLab/chromVAR) …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Cell-to-cell variation is a universal feature of life that affects a wide range of biological
phenomena, from developmental plasticity, to tumour heterogeneity. Although recent …

The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …

The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

This unit describes Assay for Transposase‐Accessible Chromatin with high‐throughput
sequencing (ATAC‐seq), a method for mapping chromatin accessibility genome‐wide. This …

The human genome sequence has profoundly altered our understanding of biology, human
diversity, and disease. The path from the first draft sequence to our nascent era of personal …

Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune
evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear …