Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
PI Thakore, AM D'ippolito, L Song, A Safi… - Nature …, 2015 - nature.com
Epigenome editing with the CRISPR (clustered, regularly interspaced, short palindromic
repeats)-Cas9 platform is a promising technology for modulating gene expression to direct …
repeats)-Cas9 platform is a promising technology for modulating gene expression to direct …
Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks
The complex language of eukaryotic gene expression remains incompletely understood.
Despite the importance suggested by many noncoding variants statistically associated with …
Despite the importance suggested by many noncoding variants statistically associated with …
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …
and disease, yet the functions and target genes of most noncoding elements remain …
The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions
Here, we introduce the 3D Genome Browser, http://3dgenome. org, which allows users to
conveniently explore both their own and over 300 publicly available chromatin interaction …
conveniently explore both their own and over 300 publicly available chromatin interaction …
Chromatin architecture reorganization during stem cell differentiation
Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …
Although dynamic chromatin structures have been identified in the genome, the full scope of …
The prevalence, evolution and chromatin signatures of plant regulatory elements
Chromatin accessibility and modification is a hallmark of regulatory DNA, the study of which
led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin …
led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
Chromosome conformation elucidates regulatory relationships in developing human brain
Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Enhancers, critical determinants of cellular identity, are commonly recognized by correlative
chromatin marks and gain-of-function potential, although only loss-of-function studies can …
chromatin marks and gain-of-function potential, although only loss-of-function studies can …