Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

The prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with
aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a …

The genetic interrogation and reprogramming of cells requires methods for robust and
precise targeting of genes for expression or repression. The CRISPR-associated …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Neuronal diversity is essential for mammalian brain function but poses a challenge to
molecular profiling. To address the need for tools that facilitate cell-type-specific epigenomic …

Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …

Understanding the difference in genetic regulation of gene expression between brain and
blood is important for discovering genes for brain-related traits and disorders. Here, we …

The term'super-enhancer'has been used to describe groups of putative enhancers in close
genomic proximity with unusually high levels of Mediator binding, as measured by chromatin …