The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Genomic and chromosomal instability are hallmarks of cancer and shape the genomic
composition of cancer cells, thereby determining their behavior and response to treatment …

PURPOSE Pembrolizumab significantly improves clinical outcomes in advanced/metastatic
microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) solid tumors but is …

Over the past two decades of successive clinical trials in metastatic colorectal cancer (CRC),
the median overall survival of both control and experimental arms has steadily improved …

Background & Aims N6-methyladenosine (m 6 A) governs the fate of RNAs through m 6 A
readers. Colorectal cancer (CRC) exhibits aberrant m 6 A modifications and expression of m …

The long-term remissions induced by immune-checkpoint inhibitors (ICIs) in many types of
cancers have opened up the possibility of a broader use of immunotherapy in less …

Colorectal cancer is one of the most common cancers in the world, and it is one of the
leading causes of cancer-related death. Despite recent progress in the development of …

Background Pembrolizumab demonstrated durable clinical benefit and manageable safety
in previously treated advanced or metastatic microsatellite instability-high (MSI-H)/mismatch …

Colorectal cancer is one of the most common cancers in the world, and it is one of the
leading causes of cancer-related death. Despite recent progress in the development of …

Purpose: Immune checkpoint inhibitors show high response rates and durable clinical
benefit in microsatellite instability–high/mismatch repair–deficient (MSI-H/dMMR) tumors …