Targeting fatty acid metabolism in glioblastoma

J Miska, NS Chandel - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …

Synthesis and significance of arachidonic acid, a substrate for cyclooxygenases, lipoxygenases, and cytochrome P450 pathways in the tumorigenesis of glioblastoma …

J Korbecki, E Rębacz-Maron, P Kupnicka, D Chlubek… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to …

S Parik, J Fernández-García, F Lodi… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma is a highly lethal grade of astrocytoma with very low median survival. Despite
extensive efforts, there is still a lack of alternatives that might improve these prospects. We …

FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer

KSD Kothapalli, HG Park, NSL Kothapalli… - Progress in Lipid …, 2023 - Elsevier
Dysregulation of fatty acid metabolism and de novo lipogenesis is a key driver of several
cancer types through highly unsaturated fatty acid (HUFA) signaling precursors such as …

Biosynthesis and significance of fatty acids, glycerophospholipids, and triacylglycerol in the processes of glioblastoma tumorigenesis

J Korbecki, M Bosiacki, I Gutowska, D Chlubek… - Cancers, 2023 - mdpi.com
Simple Summary This review discusses the synthesis and significance of fatty acids,
glycerophospholipids, and triacylglycerol in glioblastoma. The focus is on all enzymes …

New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis

JT Brenna, KSD Kothapalli - Current Opinion in Clinical Nutrition & …, 2022 - journals.lww.com
The mixture of fatty acids available to FADS2 in any tissue defines the product mixture
available for further synthesis of membrane lipids and signaling molecules and may be …

Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men

J Korbecki, D Simińska, D Jeżewski, K Kojder… - Brain Sciences, 2022 - mdpi.com
One line of research on the possible ways of inhibiting the growth of glioblastoma multiforme
(GBM), a brain tumor with a very poor prognosis, is the analysis of its metabolism, such as …

Androgen receptor expression in the various regions of resected glioblastoma multiforme tumors and in an in vitro model

D Simińska, J Korbecki, K Kojder, D Jeżewski… - International Journal of …, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is a malignant glioma, difficult to detect and with the lowest
survival rates among gliomas. Its greater incidence among men and its higher survival rate …

Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area

J Korbecki, K Kojder, D Jeżewski, D Simińska… - Brain Sciences, 2023 - mdpi.com
This study aimed to analyze solute carrier family 27 (SLC27) in glioblastoma tumors. The
investigation of these proteins will provide insight into how and to what extent fatty acids are …

construction of a risk model to predict the prognosis and immunotherapy of low-grade glioma ground on 7 ferroptosis-related genes

L Sun, B Li, B Wang, J Li, J Li - International Journal of General …, 2022 - Taylor & Francis
Purpose Ferroptosis is closely associated with tumors. The purpose of this study was to
investigate the correlation between ferroptosis and prognosis of low grade glioma (LGG) via …