Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Genetic findings have highlighted key roles for microglia in the pathology of
neurodegenerative conditions such as Alzheimer's disease (AD). A number of mutations in …

Progress in dementia research has been limited, with substantial gaps in our knowledge of
targets for prevention, mechanisms for disease progression, and disease-modifying …

Microglia, the macrophages of the brain, are vital for brain homeostasis and have been
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …

Dementia with Lewy bodies and Parkinson's disease dementia are common
neurodegenerative diseases that share similar neuropathological profiles and spectra of …

Introduction Both late-onset Alzheimer's disease (AD) and ageing have a strong genetic
component. In each case, many associated variants have been discovered, but how much …

Population-scale biobanks linked to electronic health record data provide vast opportunities
to extend our knowledge of human genetics and discover new phenotype-genotype …