Alzheimer's disease is a progressive, clinically heterogeneous, and particularly complex
neurodegenerative disease characterized by a decline in cognition. Over the last two …

Background Alzheimer's disease (AD) is characterized by robust microgliosis and
phenotypic changes that accompany disease pathogenesis. Accumulating evidence from …

DNA methylation differences in Alzheimer's disease (AD) have been reported. Here, we
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …

Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …

Abstract Cardiovascular (CV)-and lifestyle-associated risk factors (RFs) are increasingly
recognized as important for Alzheimer's disease (AD) pathogenesis. Beyond the ε4 allele of …

Alzheimer's disease (AD) has become a severe medical challenge. Advances in
technologies produced high-dimensional data of different modalities including functional …

Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …

Abstract Introduction Large variability among Alzheimer's disease (AD) cases might impact
genetic discoveries and complicate dissection of underlying biological pathways. Methods …

Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed
on the surface of microglia. It mediates multiple pathophysiological processes in various …