Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …

Background Alzheimer's disease is a debilitating and highly heritable neurological
condition. As such, genetic studies have sought to understand the genetic architecture of …

Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

Introduction Increasing evidence suggests a role for the gut microbiome in central nervous
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids …

Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction
currently revolves around lifestyle changes with much research trying to elucidate the …

Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …

Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …

Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …