Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a
crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide …

Introduction We investigated plasma proteomic markers of astrocytopathy, brain
degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset …

Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …

Alzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor
expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an …

Introduction Blood‐brain barrier (BBB) breakdown is observed in older versus younger
adults and in late‐onset Alzheimer's disease versus age‐matched controls, but its causes …

To provide better prevention and treatment, we need to understand the environmental and
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …

Background Human genetic association studies point to immune response and lipid
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …

In recent years, the inter-relationship between the innate immune system and the central
nervous system (CNS) has moved to the forefront of biomedical research, with the discovery …

Translating human genetic findings (genome-wide association studies [GWAS]) to
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …