Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets
A Sierksma, V Escott-Price, B De Strooper - Science, 2020 - science.org
To provide better prevention and treatment, we need to understand the environmental and
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease
Genetic association studies have demonstrated the critical involvement of the microglial
immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 …
immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 …
Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease
JC Lambert, A Ramirez, B Grenier-Boley… - Molecular …, 2023 - nature.com
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …
of this component has progressed over the last 10 years, thanks notably to the advent of …
Microglia and astrocytes in disease: dynamic duo or partners in crime?
SA Liddelow, SE Marsh, B Stevens - Trends in Immunology, 2020 - cell.com
Microglia–astrocyte interactions represent a delicate balance affecting neural cell functions
in health and disease. Tightly controlled to maintain homeostasis during physiological …
in health and disease. Tightly controlled to maintain homeostasis during physiological …
Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses
Fine-mapping is commonly used to identify putative causal variants at genome-wide
significant loci. Here we propose a Bayesian model for fine-mapping that has several …
significant loci. Here we propose a Bayesian model for fine-mapping that has several …
Humanized TREM2 mice reveal microglia-intrinsic and-extrinsic effects of R47H polymorphism
Alzheimer's disease (AD) is a neurodegenerative disease that causes late-onset dementia.
The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide …
The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide …
Inflammatory cascade in Alzheimer's disease pathogenesis: A review of experimental findings
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Most AD patients
develop the disease in late life, named late onset AD (LOAD). Currently, the most …
develop the disease in late life, named late onset AD (LOAD). Currently, the most …
Genetic and environmental factors in Alzheimer's and Parkinson's diseases and promising therapeutic intervention via fecal microbiota transplantation
H Wang, F Yang, S Zhang, R Xin, Y Sun - npj Parkinson's Disease, 2021 - nature.com
Neurodegenerative diseases are characterized by neuronal impairment and loss of function,
and with the major shared histopathological hallmarks of misfolding and aggregation of …
and with the major shared histopathological hallmarks of misfolding and aggregation of …
Plasma lipidome is dysregulated in Alzheimer's disease and is associated with disease risk genes
Lipidomics research could provide insights of pathobiological mechanisms in Alzheimer's
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …