The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and its
prevalence worldwide is increasing. Several studies support the pathophysiological role of …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Sarcopenia is defined as a progressive loss of skeletal muscle mass, strength, and function.
1 Sarcopenia is often associated with ageing and frailty and, more recently, has been linked …

Simple Summary Alcohol-related Liver Disease (ALD) is the leading cause of chronic liver
disorders and the first cause of hepatocellular carcinoma in developed countries …

Hepatocellular carcinoma (HCC) typically develops as consequence of liver cirrhosis, but
HCC epidemiology has evolved drastically in recent years. Metabolic dysfunction …

Simple Summary The global prevalence of metabolic-associated fatty liver disease (MAFLD)
is rising due to urbanization, obesity, poor diet, sedentary lifestyles, and genetic factors. We …

Together with its comorbidities, nonalcoholic fatty liver disease (NAFLD) is likely to rise
further with the obesity epidemic. However, the literature's evidence shows how its …

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with high incidence and
is closely related to metabolic syndrome. If not controlled, it may eventually become …