Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …

Background Ferroptosis is a newly recognized type of cell death, which is different from
traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis …