Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Parkinson's disease (PD) starts at the molecular and cellular level long before motor
symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis …

Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …

Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative
and quantitative features of biological aging and might, therefore, offer useful information for …

The design of human model systems is highly relevant to unveil the underlying mechanisms
of aging and to provide insights on potential interventions to extend human health and life …

Bone secretory proteins, termed osteokines, regulate bone metabolism and whole-body
homeostasis. However, fundamental questions as to what the bona fide osteokines and their …

The kidney is a metabolically active organ that requires energy to drive processes such as
tubular reabsorption and secretion, and shows a decline in function with advancing age …

The hallmarks of aging have been influential in guiding the biology of aging research, with
more recent and growing recognition of the interdependence of these hallmarks on age …

Immunological health has been challenging to characterize but could be defined as the
absence of immune pathology. While shared features of some immune diseases and the …