Chemotherapy offers long-term clinical benefits to many patients with advanced cancer.
However, recent evidence has linked the cytotoxic effects of chemotherapy with the de novo …

Tumors build vessels by cooption of pre-existing vasculature and de novo recruitment of
bone marrow (BM)-derived endothelial progenitor cells (EPCs). However, the contribution …

Impairment of dendritic cells (DC), the most effective activators of anticancer immune
responses, is one mechanism for defective antitumor immunity, but the causes of DC …

The mechanisms by which bone marrow (BM)-derived stem cells might contribute to
angiogenesis and the origin of neovascular endothelial cells (ECs) are controversial …

Despite early benefits seen in cancer patients treated with antivascular endothelial growth
factor (VEGF) pathway-targeted drugs, the clinical benefits obtained in terms of progression …

The growth and dissemination of tumors rely on an altered vascular network, which supports
their survival and expansion and provides accessibility to the vasculature and a route of …

Future personalized medicine strategies for assessing an individual's health require, ideally,
a noninvasive system that is capable of integrating numerous interactive factors, including …

Tumor-infiltrating myeloid cells are involved in crucial processes during tumor development.
A subset of monocytes that express the angiopoietin receptor Tie2 play an important role in …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Purpose Metronomic chemotherapy has shown efficacy in patients with metastatic breast
cancer. When used in association with targeted antiangiogenic drugs, it was more active …