Immune checkpoints in osteosarcoma: Recent advances and therapeutic potential

Y Wen, F Tang, C Tu, F Hornicek, Z Duan, L Min - Cancer letters, 2022 - Elsevier
Osteosarcoma is the most common primary malignant bone tumor and is associated with a
high risk of recurrence and distant metastasis. Effective treatment for osteosarcoma …

Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms

A Maugeri, A Calderaro, GT Patanè, M Navarra… - International Journal of …, 2023 - mdpi.com
Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …

The role of tumor-associated macrophages in osteosarcoma progression–therapeutic implications

Q Huang, X Liang, T Ren, Y Huang, H Zhang, Y Yu… - Cellular Oncology, 2021 - Springer
Background Osteosarcoma (OS) is the most common primary malignant bone tumor.
Compared with previous treatment modalities, such as amputation, more recent …

Macrophage repolarization as a therapeutic strategy for osteosarcoma

N Anand, KH Peh, JM Kolesar - International Journal of Molecular …, 2023 - mdpi.com
Macrophages are versatile immune cells and can adapt to both external stimuli and their
surrounding environment. Macrophages are categorized into two major categories; M1 …

Mesenchymal stem cells and extracellular vesicles in osteosarcoma pathogenesis and therapy

VK Sarhadi, R Daddali… - International journal of …, 2021 - mdpi.com
Osteosarcoma (OS) is an aggressive bone tumor that mainly affects children and
adolescents. OS has a strong tendency to relapse and metastasize, resulting in poor …

[HTML][HTML] miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3 …

W Liu, Q Long, W Zhang, D Zeng, B Hu, S Liu… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Enhanced infiltration of M2-polarized tumor-associated macrophages (TAMs)
is linked to osteosarcoma (OS) metastasis and growth. Here, we aim to explore a novel miR …

Molecular pathways involved in the anti-cancer activity of flavonols: a focus on myricetin and kaempferol

MR Felice, A Maugeri, G De Sarro, M Navarra… - International Journal of …, 2022 - mdpi.com
Natural compounds have always represented valuable allies in the battle against several
illnesses, particularly cancer. In this field, flavonoids are known to modulate a wide panel of …

Current state of immunotherapy and mechanisms of immune evasion in ewing sarcoma and osteosarcoma

V Evdokimova, H Gassmann, L Radvanyi… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …

Current status and prospects of clinical treatment of osteosarcoma

ZY Jiang, JB Liu, XF Wang, YS Ma… - Technology in cancer …, 2022 - journals.sagepub.com
Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …

The role of macrophages in sarcoma tumor microenvironment and treatment

AE Zając, AM Czarnecka, P Rutkowski - Cancers, 2023 - mdpi.com
Simple Summary Soft tissue and bone sarcomas belong to a group of rare and malignant
tumors. The treatment of these tumors is very complex and depends on their specific …