The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …

Magnesium is the fourth most abundant mineral in the body. It has been recognized as a
cofactor for more than 300 enzymatic reactions, where it is crucial for adenosine …

Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is
characterized by the damage of mucosal epithelium and destruction of the intestinal …

Calcium, phosphate, and magnesium are multivalent cations that are important for many
biologic and cellular functions. The kidneys play a central role in the homeostasis of these …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Inflammatory bowel diseases are characterised by inflammation that compromises the
integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has …

Magnesium is a critical mineral in the human body and is involved in~ 80% of known
metabolic functions. It is currently estimated that 60% of adults do not achieve the average …

The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …